Mr. Grissom began his career practicing law, and later became a partner in the firm of Greenebaum Grissom Doll Matthews & Boone. From 1969 to 1973 he served as Executive Vice President of Humana, Inc. From 1973 to 1989, he held various senior positions, including Chairman and CEO, of Citizens Fidelity Bank & Trust and Vice Chairman of its successor, PNC Financial Corp.
He is now Chairman of Mayfair Capital, a private investment firm. He is currently Chairman of The Glenview Trust Company. He is a former Director of Humana, Inc., Providian Financial Corp., PNC Financial, Inc., LG&E Corporation, Columbia/HCA Healthcare Corp., Regal Cinemas, Transco Energy, Inc., YUM Brands, Inc., Sphere Drake Holding, LTD, and Churchill Downs, Inc.
Mr. Grissom is a graduate of Centre College and the University of Louisville Law School. He served as Chairman of the Board of Trustees of Centre College for more than 20 years. He served as Chairman of the Kentucky Council on Higher Education, Chairman of the Louisville Chamber of Commerce, and Chairman of the Kentucky Center for the Arts. He served as Chairman of the Board of Trustees of the University of Louisville from January 2017 until December 2019.